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Studies on Griseolic Acid Derivatives X. Synthesis and Phosphodiesterase Inhibitory Activity of 2-Substituted Derivatives of Griseolic Acid

 

作者: Masakatsu Kaneko,   Misako Kimura,   Yoshinobu Murofushi,   Takashi Yasumoto,   Yasuteru Iijima,   Mitsuo Yamazaki,  

 

期刊: Nucleosides and Nucleotides  （Taylor Available online 1992）
卷期: Volume 11, issue 2-4  

页码: 865-887

 

ISSN:0732-8311

 

年代: 1992

 

DOI:10.1080/07328319208021746

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

Griseolic acid derivatives which were modified at the 2-and/or 6-positions were first synthesized from griseolic acid by a ring opening—reclosure reaction of the adenine ring. Among these derivatives, the 2-amino-6-deamino-6-hydroxyl (guanine) derivative showed 3.3 and 45 times stronger inhibitory activity against cAMP and cGMP PDE, respectively, than those of griseolic acid. Structure-activity relationships among these derivatives are also discussed.

 

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