Radioimmunoassay for the Detection of the Core of the Dane Particle and Antibody to It
作者:
Robert H. Purcell,
John L. Gerin,
June B. Almeida,
Paul V. Holland,
期刊:
Intervirology
(Karger Available online 1973)
卷期:
Volume 2,
issue 4
页码: 231-243
ISSN:0300-5526
年代: 1973
DOI:10.1159/000149428
出版商: S. Karger AG
关键词: Radioimmunoassay;Hepatitis B;Virus;Antigen;Antibody;Dane particle
数据来源: Karger
摘要:
A radioimmunoassay for detecting the core of the Dane particle and antibody to it was developed. The core was detected in concentrates of Dane particles but not in preparations of purified 22-nm forms of hepatitis B antigen. Detergent treatment of Dane particles increased the detectability of the core. Antibody to the core appeared following acute type B hepatitis infection and could be consistently demonstrated in chronic carriers of hepatitis B antigen. Such antibody was found less frequently in patients with evidence of re-exposure to hepatitis B antigen; it could not be detected in pooled hepatitis B immune serum globulin.
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