Higher retention of manganese in suckling than in adult rats is not due to maturational differences in manganese uptake by rat small intestine
作者:
JanetG. Bell,
CarlL. Keen,
Bo Lönnerdal,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 26,
issue 4
页码: 387-398
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531263
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
To test the hypothesis that the high absorption of manganese (Mn) in suckling rats compared to weanling rats is due in part to maturational differences in mucosal cell uptake of Mn, uptake kinetics of Mn were examined in isolated brush‐border membrane vesicles prepared from the small intestine of rats at various ages (d 14, d 18, d 21). Initial uptake of Mn was rapid by vesicles from all age groups and reached an equilibrium plateau by 5 min in vesicles from suckling rats (d 14) and 10 min in vesicles from weanling rats (d 18, d 21). Uptake of Mn was associated with an osmoti‐cally active space.
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