Carcinoembryonic Antigen Isotypes in Tissue Sections and Loose Cyst Fluid Cells of Ovarian Neoplasms
作者:
Antonina Harłozińska,
Julia K. Bar,
Serge Jothy,
Pawel Sedlaczek,
Barbara Ślesak,
Roman Richter,
期刊:
Tumor Biology
(Karger Available online 1993)
卷期:
Volume 14,
issue 1
页码: 1-8
ISSN:1010-4283
年代: 1993
DOI:10.1159/000217819
出版商: S. Karger AG
关键词: Carcinoembryonic antigen epitopes;Ovarian neoplasms;Immunohistochemistry;Monoclonal antibody;Tumor marker
数据来源: Karger
摘要:
The aim of this study was to establish whether different subsets of ovarian neoplasms express a restricted isotype of carcinoembryonic antigen (CEA) which can be detected in solid tumors and detached cells. Sixty-one cases of mucinous. serous, endometrioid, and Krukenberg tumors were studied by immunohistochemistry using two monoclonal antibodies (MAbs), commercial anti-CEA and D14 with a higher speeificity for colorectal adenocarcinomas. The results with both antibodies showed a considerable degree of heterogeneity between cases of nonserous tumors, with a more restrictive pattern observed with the Dl4 MAb. The proportion of immuno-stained cells was comparable in tumors and fluids.
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