A Randomized Study Comparing the Efficacy of Reducing the Spontaneous Abortion Rate following Lymphocyte Immunotherapy and Progesterone Treatment versus Progesterone Alone in Primary Habitual Aborters
作者:
Jerome H. Check,
Paula Tarquini,
Pauline Gandy,
Carolyn Lauer,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1995)
卷期:
Volume 39,
issue 4
页码: 257-261
ISSN:0378-7346
年代: 1995
DOI:10.1159/000292421
出版商: S. Karger AG
关键词: Leukocyte immunization;Luteal phase defect
数据来源: Karger
摘要:
Presented herein is a randomized prospective study performed to evaluate the efficacy of the addition of lymphocyte immunotherapy (LI) to progesterone (P) therapy (LI/P) for the prevention of spontaneous abortion (SAB) in primary aborters with a history of three SABs. The incidence of intrauterine pregnancies in four cycles was 23 of 35 (65.7%) patients for LI/P vs. 14 of 31 (45.1%) patients treated with progesterone alone. SABs occurred in 6 of 23 (26.0%) Ll/P-treated patients compared to 8 of 14 (57.1%) given progesterone alone. The mean number of previous abortions in both groups was 3.9. The mean age of the LI/P group was 34.1 vs. 33.6 years for the group treated with progesterone alone. These data could be interpreted to show that progesterone therapy and LI independently inhibit SAB or that LI/P acts synergistically to inhibit immune destruction. LI/P therapy was found to be more effective than progesterone therapy alone.
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