2-Hydroxypropyl methacrylate (2-HPMA) has been copolym-erized with ethyl methacrylate (EMA), n-butyl methacrylate (BMA), and 2-ethylhexyl methacrylate (EHMA) in bulk at 60°C using benzoyl peroxide as initiator. The copolymer composition has been determined from the hydroxyl content. The reactivity ratios have been calculated by the Yezrielev, Brokhina, and Raskin method. For copolymerization of 2-HPMA (M1) with EMA (M2), the reactivity ratios are r1= 1.807 ± 0.032 and r2= 0.245 ± 0.021; with BMA (M2) they are n = 2.378 ± 0.001 and r2= 0.19 ± 0.01; and with EHMA the values are r1= 4.370 ± 0.048 and r2= 0.103 ± 0.006. Since reactivity ratios are the measure of distribution of monomer units in copolymer chain, the values obtained are compared and discussed. This enables us to choose a suitable copolymer for synthesizing thermoset acrylic polymers, which are obtained from cross-linking of hydroxy functional groups of HPMA units, for specific end-uses.