Different sister chromatid exchange rates in XX and XY cells of a pair of human chimeric twins
作者:
H.C. Wulf,
E. Niebuhr,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1985)
卷期:
Volume 39,
issue 2
页码: 105-108
ISSN:1424-8581
年代: 1985
DOI:10.1159/000132116
出版商: S. Karger AG
数据来源: Karger
摘要:
To explore the influence of sex on sister chromatid exchange (SCE) level, a pair of chimeric twins was examined for differences in SCE frequency between the XX and XY cells present in each individual. By this method, the influence of possible differences in environmental exposure was eliminated. SCE levels were varied by growing the cells in media containing 0, 1.3 × 10–7, or 6.5 × 10–7 M melphalan. XX cells showed a higher SCE count than XY cells. This difference increased with increasing SCE level and ranged from 5.4% to 7.8% (P = 0.0003) of the SCE counts. Only about 2% of the difference could be explained by the higher amount of DNA present in the XX cells than in the XY cells. In this case XX cells seemed to be more sensitive to SCE-inducing agents than XY
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