A Case of Bullous Pemphigoid with Antidesmoplakin Autoantibodies
作者:
K. Watanabe,
T. Hashimoto,
A. Ishiko,
H. Shimizu,
T. Nishikawa,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 1
页码: 126-128
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246953
出版商: S. Karger AG
关键词: Bullous pemphigoid;Desmoplakin;Paraneoplastic pemphigus
数据来源: Karger
摘要:
We present an 84-year-old Japanese male showing typical features of bullous pemphigoid (BP). However, immunofluorescence of normal human skin sections revealed concurrent anti-basement-membrane-zone and anti-keratinocyte-cell-surface autoantibodies in the serum. With immunoblotting, the patient’s serum reacted with desmoplakins I and II, as well as with both the 230-kD and the 180-kD BP antigens. The studies for this case may provide us with an insight to understand the occurrence of antidesmoplakin antibodies in paraneoplastic pemphigu
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