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Elevated Serum Group II Phospholipase A2Levels Are Associated with Decreased Blood Flow Velocity in the Umbilical Artery

 

作者: Martti O. Pulkkinen,   Anna-Kaisa Poranen,   Asko I. Kivikoski,   Timo J. Nevalainen,  

 

期刊: Gynecologic and Obstetric Investigation  (Karger Available online 1996)
卷期: Volume 41, issue 2  

页码: 93-95

 

ISSN:0378-7346

 

年代: 1996

 

DOI:10.1159/000292050

 

出版商: S. Karger AG

 

关键词: Phospholipase A2;Pulsatile Doppler sonography;Preeclampsia;Umbilical blood flow

 

数据来源: Karger

 

摘要:

Twenty-two hospitalized patients, diagnosed as having hypertensive disorder of pregnancy, were selected from two University Clinics. Maternal serum samples were analyzed for serum group II phospholipase A2 (PLA2-II) by time-resolved fluoroimmunoassay. At the same time, umbilical artery blood flow velocities were measured with color Doppler sonography for orientation and pulsatile Doppler sonography for recording waveforms. Nineteen normoten-sive third-trimester pregnant patients served as a control group. Maternal serum PLA2-II was elevated in 8 cases with preeclampsia. This elevation was invariably associated with decreased blood flow velocity in the umbilical artery. In 1 case, the clinical condition allowed simultaneous follow-up of serum enzyme and blood flow velocity: a further rise of serum PLA2-II was linked to a further decrease in the blood flow velocity of the umbilical artery. A large spillover of the elevated PLA2-II content from the preeclamptic placenta into the maternal serum is associated with a decrease in blood flow velocity in the umbilical artery. The enzyme might serve as a link between local proximal (placenta) and systemic distal (umbilical arterial blood flow) effectors.

 

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