首页   按字顺浏览 期刊浏览 卷期浏览 Cytotocidal Mechanism of TNF: Effects of Lysosomal Enzyme and Hydroxyl Radical Inhibito...
Cytotocidal Mechanism of TNF: Effects of Lysosomal Enzyme and Hydroxyl Radical Inhibitors on Cytotoxicity

 

作者: WatanabeNaoki,   NiitsuYoshiro,   NedaHiroshi,   SoneHisao,   YamauchiNaofumi,   MaedaMasahiro,   UrushizakiIchiro,  

 

期刊: Immunopharmacology and Immunotoxicology  （Taylor Available online 1988）
卷期: Volume 10, issue 1  

页码: 109-116

 

ISSN:0892-3973

 

年代: 1988

 

DOI:10.3109/08923978809014405

 

出版商: Taylor&Francis

 

关键词: Tumor Necrosis Factor(TNF);Lysosomal enzyme;Hydroxyl radical;Cytocidal mechanism

 

数据来源: Taylor

 

摘要:

AbstractThe participation of lysosomal enzymes, hydroxyl radicals, and mitochondrial respiration in the cytocidal effect of TNF on tumor cells was investigated.The cytotoxicity of TNF on L-M cells was clearly reduced by lysosomotropic agents, DMSO (hydroxyl radical scavenger), NDGA (lipoxygenase inhibitor), and sodium azide (mitochondrial respiration inhibitor).The results suggest that lysosomal enzyme and hydroxyl radicals play an important triggering role in the destruction of tumor cells by TNF, and that the process of destruction might require ATP.

 

点击下载:  PDF (266KB)



返 回