Effect of Cimetidine on Basal and Histamine-induced Secretion of Parathyroid Hormone in vitro
作者:
P.K. Wagner,
U. Krause,
T. Schärfe,
J. Beyer,
M. Rothmund,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 36,
issue 2
页码: 89-93
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183124
出版商: S. Karger AG
关键词: Cimetidine;Histamine;PTH release in vitro;Single cell suspension
数据来源: Karger
摘要:
The effect of cimetidine on basal and histamine-induced PTH secretion was tested using single cell suspensions obtained from (a) primary parathyroid adenomas, and (b) secondary hyperplastic parathyroid tissue from patients undergoing chronic hemodialysis. The histamine-stimulated hormone secretion was dose-dependent. Cimetidine suppressed both basal and histamine-stimulated hormone secretion. Within the therapeutic range the suppressive effect was identical for adenoma and hyperplasia. Both adenomata and secondary hyperplastic glands showed a histamine H2-receptor-related response. The role of histamine in the pathogenesis of hyperparathyroidism is not quite clear so that the possible benefits of cimetidine for medical treatment of primary and secondary hyperparathyroidism will have to be proven by careful clinical trials.
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