Atypical Pemphigus with Concomitant IgG and IgA Anti-Intercellular Autoantibodies Associated with Monoclonal IgA Gammopathy
作者:
H. Ohno,
S. Miyagawa,
T. Hashimoto,
A. Nakagawa,
K. Watanabe,
T. Nishikawa,
T. Shirai,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 1
页码: 115-116
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246948
出版商: S. Karger AG
关键词: Atypical pemphigus;Monoclonal IgA gammopathy;IgA anti-intercellular antibodies
数据来源: Karger
摘要:
A case is reported of a 60-year-old woman with acantholytic vesiculopustular dermatosis and IgA-λ monoclonal gammopathy. The histopathology of vesiculopustular lesions showed intraepidermal acantholytic and neutrophilic blisters. Direct immunofluorescence revealed intercellular (IC) IgG deposition with concurrent deposits of IgA and C3. Indirect immunofluorescence and immunoblotting studies revealed that the patient had circulating IgG and IgA anti-IC antibodies both of which recognized the 150-kD desmoglein that was pemphigus foliaceus antigen in a bovine desmosome preparation
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