Studies on Four Restriction Fragment Length Polymorphisms of the Type I Collagen Genes in Two Italian Populations
作者:
Guglielmina Pepe,
Mariella Muglia,
Carlo Brancati,
Guido Modiano,
期刊:
Human Heredity
(Karger Available online 1990)
卷期:
Volume 40,
issue 6
页码: 368-380
ISSN:0001-5652
年代: 1990
DOI:10.1159/000153961
出版商: S. Karger AG
关键词: RFLPs;Haplotypes;Population genetics;Type I collagen
数据来源: Karger
摘要:
Type I collagen, the most abundant of the collagen protein family, is encoded by two genes, COL1A1 and COL1A2. Two random population samples, one from central Italy and one from southern Italy, were studied for 1 restriction fragment length polymorphism (RFLP) of COL1A1 (Rsal) and 3 RFLPs of COL1A2 (EcoRI, RsaI and MspI). A considerable heterogeneity for COL1A1/Rsal was found not only between Italians and English but even among Italians. The potential usefulness of these RFLPs and haplotypes as anthropogenetic markers, particularly in distinguishing Caucasoids from Negroids, has been discussed.
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