Fetal Liver Transplantation in 2 Patients with Acute Leukaemia after Total Body Irradiation
作者:
Guido Lucarelli,
Teodosio Izzi,
Adolfo Porcellini,
Costantino Delfini,
Mariella Galimberti,
Luciano Moretti,
Paola Polchi,
Fabrizio Agostinelli,
Marco Andreani,
Marisa Manna,
Bruno Dallapiccola,
期刊:
Scandinavian Journal of Haematology
(WILEY Available online 1982)
卷期:
Volume 28,
issue 1
页码: 65-71
ISSN:0036-553X
年代: 1982
DOI:10.1111/j.1600-0609.1982.tb02122.x
出版商: Blackwell Publishing Ltd
关键词: acute leukaemia;fetal liver transplantation
数据来源: WILEY
摘要:
2 patients with acute leukaemia in relapse were transplanted with fetal liver cells following a conditioning regimen of cyclophosphamide (120 mg/kg) and total body irradiation (1000 r). Each patient achieved a remission with haematopoietic recovery that was rapid in one case and delayed in the other. In one case there was evidence of chimerism as demonstrated by the presence of the XYY karyotype of the donor fetus in 20% of marrow metaphases, by the presence of double Y bodies in the peripheral blood, by the appearance of new HLA‐antigens, and by red cell isoenzyme phenotypes of donor origin. In the second case there was prompt haemotopoietic recovery and the appearance of red cell isoenzyme phenotypes of donor origin. Survival was 153 and 30 d, respectively, and both patients died of interstitial pneumonia without evidence of graft versus host diseas
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