HPLC Analysis of Metronidazole and Diloxanide Furoate in Its Dosage Forms
作者:
S.M. El-Gizawy,
期刊:
Analytical Letters
(Taylor Available online 1995)
卷期:
Volume 28,
issue 1
页码: 83-92
ISSN:0003-2719
年代: 1995
DOI:10.1080/00032719508006019
出版商: Taylor & Francis Group
关键词: Metronidazole;Diloxanide Furoate;HPLC
数据来源: Taylor
摘要:
A high performance liquid chromatographic method for the simultaneous determination of metronidazole and diloxanide furoate in single and combined dosage form has been developed. Each drug acted as internal standard for the other. Both of the drugs eluted from the cyclobond column (β-cyclodextrin stationary phase) without retardation effects, using methanol-0.05 M NaH2PO4(pH 7) in ratio 35:65, flow rate 1 ml min−1and detection at 254 nm. Metronidazole and diloxanide furoate gave rectilinear calibration graphs in the ranges 1–10 μg and 1–5 μg respectively.
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