Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C‐related hemolytic‐uremic syndrome
作者:
Juan Monteagudo,
Arturo Pereira,
Susana Roig,
Juan C. Reverter,
Antonio Ordinas,
Ricardo Castillo,
期刊:
American Journal of Hematology
(WILEY Available online 1990)
卷期:
Volume 33,
issue 1
页码: 46-49
ISSN:0361-8609
年代: 1990
DOI:10.1002/ajh.2830330109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: thrombotic thrombocytopenic syndromes;vWF structure;platelet aggregation;chemotherapy agents
数据来源: WILEY
摘要:
AbstractWe have studied the ability of the plasma to induce aggregation of both homologous and heterologous platelets in four patients with hemolytic‐uremic syndrome (HUS) associated with chemotherapy with mitomycin C (MMC). Neither platelet aggregation was elicited by patients' plasmas nor the in vitro addition of purified von Willebrand factor (vWF) had any effect on the aggregation pattern. In addition, ristocetin‐induced binding of patients' vWF to formaldehyde‐fixed platelets was normal, and multimeric vWF analysis revealed a normal structure of patients' plasmatic vWF whatever the clinical stage in which it was studied. These findings suggest that, in spite of the existence of common clinical and biological features in the various forms of HUS, the pathogenesis of MMC‐related HUS may be, at least in part, different from that of the other forms of HUS in which both platelet‐aggregating activity and alterations in the vWF
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