Recovery of the Cortical Evoked Response Following Temporary Middle Cerebral Artery Occlusion in BaboonsRelation to Local Blood Flow and Po2
作者:
NEILM. BRANSTON,
LINDSAY SYMON,
H. A. CROCKARD,
期刊:
Stroke
(OVID Available online 1976)
卷期:
Volume 7,
issue 2
页码: 151-157
ISSN:0039-2499
年代: 1976
出版商: OVID
数据来源: OVID
摘要:
The degree of recovery of the somatosensory cortical evoked response following a period (15 to 65 minutes) of partial ischemia, produced by temporary occlusion of the middle cerebral artery (MCA), was assessed in baboons and related to the local tissue blood flow and Pth before, during and after the occlusion. Flow was measured using the technique of two-minute hydrogen clearance. Failure of complete recovery of the evoked response was associated with significantly greater depths of ischemia and tissue hypoxia during occlusion, and with significantly greater and persisting tissue hypoxia after occlusion, than complete recovery. Complete recovery of the eioked response also was associated with tissue hyperoxia after occlusion. The reduced postocclusive Po2 levels associated with incomplete recovery of the evoked response suggest that reduced perfusion during ischemia was sufficiently severe to cause some degree of irreversible anoxic damage. The effect of a brief (three to ten minutes) period of ventilation with air (instead of oxygen) under such low-now conditions was to depress the evoked response significantly further; normally perfused brain, however, was unaffected by this procedure. This finding has clinical implications in regard to normobaric oxygen therapy.
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