A case of marked skin fragility in a 4‐month‐old pet rabbit is described. The clinical findings, gross pathology, histopathology, and ultrastructure of skin samples were consistent with Ehlers‐Danlos‐like syndrome. This syndrome is recognized in many animal species and is often compared to Ehlers‐Danlos syndrome in humans. Ehlers‐Danlos‐like syndromes in animals are reviewed and possible similarities between these disorders and Ehlers‐Danlos syndrome in humans are discussed.