Localization of the Murine Leukemia Inhibitory Factor Gene Near the Centromere on Chromosome 11
作者:
KolaIsmail,
DaveyAnna,
GoughNicholas M.,
期刊:
Growth Factors
(Taylor Available online 1990)
卷期:
Volume 2,
issue 2
页码: 235-240
ISSN:0897-7194
年代: 1990
DOI:10.3109/08977199009071509
出版商: Taylor&Francis
关键词: leukemia inhibitory factor (LIF);DIA;D-factor;ES cells;EC cells
数据来源: Taylor
摘要:
AbstractLeukemia inhibitory factor (LIF) is a glycoprotein with divergent activities: It induces the differentiation of certain myeloid leukemic cells, inhibits the differentiation of embryonic stem cells, and promotes bone remodellingin vivoandin vitro.The murine LIF gene has been assigned to the proximal region of chromosome 11 at sub-bands A1-A2, by analysis of a panel of mouse x Chinese hamster somatic cell hybrids and byin situhybridization. Interestingly, the proximal portion of chromosome 11 has been shown, by virtue of its parental origin effects, to contain gene(s) involved in fetal growth. It is also interesting that there is a preponderance of chromosome 11 abnormalities in embryonal carcinoma cells. The localization of the murine LIF gene confirms the homology of a portion of murine chromosome 11 with human chromosome 22q, the site of the human LIF gene.
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