Free Phenytoin Monitoring in Serum and Saliva of Epileptic Patients in China
作者:
Wei Cai,
Guang Zhu,
Gang Chen,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1993)
卷期:
Volume 15,
issue 1
页码: 31-34
ISSN:0163-4356
年代: 1993
出版商: OVID
关键词: Free phenytoin;Equilibrium dialysis;Saliva;Epilepsy;Fluorescence polarization immunoassay
数据来源: OVID
摘要:
Twenty-three serum samples and 13 saliva samples from 14 Chinese epileptic patients treated with phenytoin (DPH) were obtained to study the correlations between total, free serum, and saliva DPH concentrations. The binding of DPH to serum protein was assessed by equilibrium dialysis, and total and free DPH concentrations were analyzed with a domestic fluorescence polarization immunoassay reagent by the TDx system. A strong correlation existed between the total and free concentrations (r= 0.90, n = 20,p< 0.001). The mean value for the DPH free fraction was 11.13 ± 3.65%. The mean, value for the saliva fraction was 9.40 ± 2.60%. This is the first attempt to monitor free DPH concentrations in serum in Chinese patients.
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