Lipids in the Progression of Chronic Renal Failure
作者:
P. Cappelli,
M. Evangelista,
M. Bonomini,
P.F. Palmieri,
A. Albertazzi,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 1
页码: 31-35
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186991
出版商: S. Karger AG
关键词: Apolipoproteins;Chronic renal failure;Lipids;Urinary protein excretion
数据来源: Karger
摘要:
Lipid disturbances have been linked to the progression of chronic renal disease. We examined 52 patients with a creatinine clearance (CCr) of 38.5 ± 7.9 ml/min due to various nephropathies, on free diet. Bimonthly, over a 12-month period, we assessed: serum creatinine (Cr); CCr; daily urinary urea excretion; urinary protein excretion per unit of residual renal function (UProt/CCr); total, HDL, VLDL and LDL cholesterol; triglycerides; Apo A, Apo B. Chronic renal failure was progressive in 22 patients with a slope of 1/Cr-0.00358 ± 0.00247, stable in 30 with a slope of 0.00420 ± 0.00285. Lipid parameters did not differ significantly between the two groups but for the lower Apo A and Apo A/Apo B ratio values in the progressive group. Overall slope inversely correlated with basal CCr; in the progressive patients the slope correlated with the percentage variation of UProt/CCr and only partially with the altered Apo profi
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