The risk factor profile of recto-sigmoid adenomas: a prospective screening study of 665 patients in a clinical rehabilitation centre
作者:
B Manus,
R P Adang,
A W Ambergen,
R Brägelmann,
U Armbrecht,
R W Stockbrügger,
期刊:
European Journal of Cancer Prevention
(OVID Available online 1997)
卷期:
Volume 6,
issue 1
页码: 38-43
ISSN:0959-8278
年代: 1997
出版商: OVID
关键词: Alcohol;blood glucose;body weight;cholesterol;gastric surgery;gastrin;heredity;polyps;rectosigmoid adenomatous risk factors;smoking;triglycerides
数据来源: OVID
摘要:
During a prospective screening study for recto-sigmoid adenomatous polyps, the influence of the following risk factors was evaluated: age; gender; body mass index; heredity for colorectal malignancy; diabetes; hypertension; constipation; previous gastric surgery; previous gastric add inhibition; alcohol and cigarette consumption; serum cholesterol; serum triglycerides; and serum gastrin. Screening fibre-sigmoidoscopy of 665 patients (aged between 50 and 60 years) at a clinical rehabilitation centre for gastrointestinal and metabolic diseases showed that 146 had one or several adenomas. The study population was overweight by a mean of about 15%. Comparison of those with and those without adenoma using univariate analysis, showed that the group with adenomas had higher serum triglyceride values, drank more alcohol on a regular or excessive basis, were more frequent smokers, and had a tendency to raised fasting serum glucose. In a multivariate analysis, age, high serum triglycerides and high alcohol consumption were risk factors for recto-sigmoid adenomas. The risk factor profile identified in this study may help in the selection of individuals for screening sigmoidoscopy from a similar background population. It also identifies target conditions for primary prevention of colorectal neoplasia.
点击下载:
PDF
(469KB)
返 回