Prolactin Suppression by Serotonin Antagonists in Man: Further Evidence for Serotoninergic Control of Prolactin Secretion
作者:
C. Ferrari,
R. Caldara,
M. Romussi,
P. Rampini,
P. Telloli,
S. Zaatar,
G. Curtarelli,
期刊:
Neuroendocrinology
(Karger Available online 1978)
卷期:
Volume 25,
issue 6
页码: 319-328
ISSN:0028-3835
年代: 1978
DOI:10.1159/000122753
出版商: S. Karger AG
关键词: Serotonin;Serotonin antagonists;Dopamine antagonists;Prolactin secretion
数据来源: Karger
摘要:
To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p < 0.001) in serum Prl were observed at 120, 180, and 240 min following the oral administration of metergoline (Met) (4 mg; N = 34) and methysergide (Meth) (3 mg; N = 20) in comparison with placebo. No significant difference was found in the degree of Prl suppression induced by these two serotonin antagonists and by the dopaminergic drug bromocriptine (Br) (2.5 mg; N = 20). After Pim pretreatment (1 mg every 6 h for 7 days) the elevated serum Prl levels were reduced to 27.1% ± 8.1 (SEM) of basal after Met and to 54.5% ± 8.9 after Meth administration (N = 5 for each study). It is concluded that Met and Meth inhibit Prl secretion by mechanisms which are not or only partially related to dopaminergic receptors. These data are consistent with a stimulatory role for serotonin in human Prl releas
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