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The Elston-Stewart Algorithm for Continuous Genotypes and Environmental Factors

 

作者: Robert C. Elston,   Varghese T. George,   Forrestt Severtson,  

 

期刊: Human Heredity  (Karger Available online 1992)
卷期: Volume 42, issue 1  

页码: 16-27

 

ISSN:0001-5652

 

年代: 1992

 

DOI:10.1159/000154043

 

出版商: S. Karger AG

 

关键词: Multinomial density;Familial correlations;Pedigree analysis;Polygenic model

 

数据来源: Karger

 

摘要:

The Eiston-Stewart algorithm for a normally distributed trait under a polygenic model is explained in detail and extended to allow for other continuous environmental variables. This formulation is especially useful for large pedigrees, as it avoids the need to invert matrices. Whereas it may not be feasible by this method to estimate all the various components of previously suggested models for polygenic inheritance, it can allow for a reasonably flexible pedigree correlational structure under which valid tests can be performed for fixed effects that may affect the phenotype.

 

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