Evidence for feedback mediated reduction of glomerular filtration rate during infusion of acetazolamide
作者:
A. ERIK G. PERSSON,
FRED S. WRIGHT,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1982)
卷期:
Volume 114,
issue 1
页码: 1-7
ISSN:0001-6772
年代: 1982
DOI:10.1111/j.1748-1716.1982.tb06945.x
出版商: Blackwell Publishing Ltd
关键词: Rat;tubulo‐glomerular feedback;carbonic anhydrase inhibitor;macula densa;proximal tubule;distal tubule;sodium;chloride;bicarbonate
数据来源: WILEY
摘要:
Systemic administration of acetazolamide (ACZ) causes glomerular filtration rate (GFR) to fall. Clearance and micropuncture experiments were done to define the mechanism of this drug effect. When rats were infused with ACZ intravenously, kidney GFR fell by 30% and single nephron (SN) GFR (measured by collecting distal tubule fluid) fell by 23%. Changes in arterial blood pressure, arterial pH, extracellular fluid volume, and proximal tubule pressure were not sufficient to account for the decrease in GFR. When SNGFR was measured by collecting proximal tubule fluid, with the loop of Henle having been blocked for 2–5 min, SNGFR was higher than the distally measured value and was not different than control. The results are consistent with the fall in GFR being caused by activation of the tubulo‐glomerular feedback mechan
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