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Steroid Biosynthetic Potential of Gynaecomastic Tissue in Man

 

作者: K.G. Rajendran,   Prabhaker N. Shah,   Nargis P. Bagli,   Sudha S. Mhtry,   S.N. Ghosh,  

 

期刊: Hormone Research in Paediatrics  （Karger Available online 1975）
卷期: Volume 6, issue 5-6  

页码: 329-335

 

ISSN:1663-2818

 

年代: 1975

 

DOI:10.1159/000178682

 

出版商: S. Karger AG

 

关键词: Gynaecomastic tissue;Biotransformation;Androstenedione;Testosterone;5α-Reductase;Aromatizing enzymes;Urinary oestrogens

 

数据来源: Karger

 

摘要:

In vitro transformation of precursors to androgens and oestrogens was studied in breast tissues from 7 phenotypic males with gynaecomastia and 3 normal females. All the tissues studied showed formation of dihydrotestosterone and oestrogens, thus demonstrating the presence of 5α-reductase and aromatizing enzymes. The results on the values of urinary oestrogens before and after surgical removal of the breast tissue substantiate the biosynthetic potential of gynaecomastic tissue. The aetiological significance of these findings vis-à-vis gynaecomastia is discusse

 

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