Calcium Channel Blockers in Systemic Hypertension
作者:
William H. Frishman,
期刊:
American Journal of Nephrology
(Karger Available online 1987)
卷期:
Volume 7,
issue 1
页码: 57-66
ISSN:0250-8095
年代: 1987
DOI:10.1159/000167544
出版商: S. Karger AG
关键词: Calcium channel blockers;Systemic hypertension;Nifedipine;Verapamil;Diltiazem
数据来源: Karger
摘要:
Calcium channel blockers selectively inhibit transmembrane flux of calcium in excitable tissue. Their ability to block calcium-mediated electromechanical coupling in contractile tissue produces peripheral vasodilation and has led to their clinical use in patients with systemic hypertension. The drugs appear to be well tolerated and have excellent safety profiles. Sustained-release preparations allow the drugs to be used once or twice daily. The calcium channel blockers will play an important role in the management of patients with mild, moderate, and severe hypertension when used as monotherapy or when combined with other antihypertensive medications. They can also be used in patients with concomitant diseases, such as angina pectoris and arrhythmia.
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