BackgroundA mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension.ObjectiveTo determine whether this observation could be confirmed with a different population sample.DesignWe examined 414 individuals with primary hypertension and 172 normotensive controls.MethodsThe mutation in the gene for the AT1receptor was detected using restriction polymerase chain reaction.ConclusionsWe detected no association of the AT1receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the1166C allele among hypertensive patients with a late age at diagnosis (≥ 50 years) was observed.