Sodium Channel Blockers Alter Slow-Wave Frequency of the Rat Stomach in vivo
作者:
Klaus Bielefeldt,
Paul Bass,
期刊:
Digestion
(Karger Available online 1991)
卷期:
Volume 48,
issue 1
页码: 43-50
ISSN:0012-2823
年代: 1991
DOI:10.1159/000200662
出版商: S. Karger AG
关键词: Sodium channel blockade;Antiarrhythmic drugs;Myoelectrical activity
数据来源: Karger
摘要:
Treatment with sodium-channel-blocking agents is accompanied by a high incidence of gastrointestinal side effects. We therefore studied the influence of two sodium channel blockers, mexiletine and flecanaide, on gastric and jejunal myoelectrical activity of unanesthetized rats. Bipolar electrodes were implanted chronically on the serosal surface of the antrum or the jejunum of male rats (weight: 250–350 g). Electrical activity was recorded on a Polygraph starting on day 5 after the operation. After 1 h of baseline recordings, either vehicle or an active drug was given randomly. Recordings were continued for 4 h after drug administration. Vehicle did not induce changes in slow-wave frequency. In contrast, gastric slow-wave activity significantly decreased after the administration of both mexiletine and flecanaide. Jejunal myoelectrical activity was only slightly affected by sodium channel blockade. The disruption of gastric myoelectrical activity may contribute to the side effects observed during chronic treatment with class I antiarrhythmic drug
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