Mechanism of protection by zinc against mercuric chloride toxicity in rats: Effects of zinc and mercury on glutathionine metabolism
作者:
Hideki Fukino,
Masami Hirai,
YuMei Hsueh,
Satoshi Moriyasu,
Yasuhiro Yamane,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 19,
issue 1
页码: 75-89
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530908
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
To investigate the mechanism by which zinc suppresses mercury toxicity, the effects of zinc and mercury on giutathione (GSH) metabolism in the rat kidney were studied. When the time course of GSH level in the rat kidney was examined at 2, 6, and 12 h after treatment of rats with both metals, an increase of GSH was found and was apparently related to the activation of some GSH‐associated enzymes. In the kidney of rats treated with both metals, the response of the protective function involving GSH and GSH‐associated enzymes depended on the magnitude of mercury toxicity but appeared to be independent of the zinc dosage. The administration of diethyl maleate (DEM), which depletes GSH, increased lipid peroxidation and mercury toxicity concomitantly with a decrease of GSH level in the kidney of rats treated with zinc and mercury. In conclusion, the data suggest that an increased GSH level in the kidney resulting from the activation of GSH‐associated enzymes plays a role in the protective effect of zinc against mercury toxicity.
点击下载:
PDF (606KB)
返 回