Colorimetric Determination of Two Nonsteroidal Anti-inflammatory Drugs Using P-Dimethylaminocinnamaldehyde
作者:
ZeinabA. El Sherif,
M.I. Walash,
M.F. El-Tarras,
AfafO. Osman,
期刊:
Analytical Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 10
页码: 1881-1896
ISSN:0003-2719
年代: 1997
DOI:10.1080/00032719708001705
出版商: Taylor & Francis Group
关键词: Colorimetric;Non steroidal Anti-inflammatory Drugs;Diclofenac Sodium;Mefenamic Acid;P-dimethylaminocinnam-aldhyde.
数据来源: Taylor
摘要:
A colorimetric method for the quantitative determination of diclofenac sodium and mefenamic acid in pure form and in pharmaceutical preparations was developed. It was based on the inter-action of the secondary aromatic amine with p-dimethyl-aminocinnamaldhyde in acidified absolute methanol medium to form very stable red [λmaxat 538 nm in case of diclofenac sodium] or blue [λmaxat 665 nm in case of mefenamic acid] products. Beer's law was obeyed over the ranges 10–80 μg ml−1and 1–8 μg ml−1for diclofenac sodium and mefenamic acid, respectively. The reactants were heated on a boiling water bath for 6 and 5 mins for each drug, respectively. Optimization of the different experimental conditions were studied. The mean percentage recoveries were found to be 100.73 ± 0.87% & 100.73 ± 0.44%, respectively. The method was applied successfully for the determination of some pharmaceutical formulations.
点击下载:
PDF (405KB)
返 回