Target Organ Susceptibility and Autoantibody Production in an Animal Model of Spontaneous Autoimmune Thyroiditis
作者:
MaczekC.,
NeuN.,
WickG.,
HalaK.,
期刊:
Autoimmunity
(Taylor Available online 1992)
卷期:
Volume 12,
issue 4
页码: 277-284
ISSN:0891-6934
年代: 1992
DOI:10.3109/08916939209148470
出版商: Taylor&Francis
关键词: Autoimmunity;thyroiditis;obese strain chickens;target-organ;autoantibodies
数据来源: Taylor
摘要:
FI-hybrids of Obese strain (OS) chickens, afflicted with spontaneous autoimmune thyroiditis (SAT), and normal, inbred CB chickens, do not develop severe thyroiditis. About 50% of these crosses show circulating autoantibodies to thyroglobulin (TgAAb), but the thyroid glands are only slightly infiltrated, suggesting that the target organ is not susceptible to autoimmune attack.In the present study we show that despite this mild infiltration TgAAb are only synthesized by lymphoid cells within the thyroid gland. Furthermore, we demonstrate that immunization with chicken thyroglobulin (Tg) in complete Freund's adjuvant causes severe experimental autoimune thyroiditis (EAT) in F1(OSxCB) hybrids.
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