Stress analysis using finite element models is now being implemented in prosthetics to overcome empirical socket design procedures and to further improve computer-aided systems. This article describes the use of anatomical data from magnetic resonance images of a single subject to produce a generic mathematical model of the residual soft tissues and skeletal structure. The model, validated through experimentally measured parameters, was employed to theoretically evaluate the mechanical behavior of tissues, predict interface stresses, and aid in shaping the socket. Numerical analysis could improve socket design criteria and advance rehabilitation services to enhance the quality of life of individuals with amputations.