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Effect of Phenazone (Antipyrine) on the Prostanoid Formation in Human Umbilical Arteries Perfused in vitro

 

作者: G. Haugen,   S. Stray-Pedersen,   K. Bjøro,  

 

期刊: Gynecologic and Obstetric Investigation  （Karger Available online 1995）
卷期: Volume 39, issue 1  

页码: 8-10

 

ISSN:0378-7346

 

年代: 1995

 

DOI:10.1159/000292366

 

出版商: S. Karger AG

 

关键词: Umbilical artery;Phenazone;Antipyrine;Prostacyclin;Thromboxane A2

 

数据来源: Karger

 

摘要:

The influence of phenazone on the production of prostacyclin and thromboxane in human umbilical arteries was investigated by in vitro perfusion. With perfusate concentrations ranging from 10––7 to 10––4M a decrease in the formation of both prostanoids was observed. The inhibitory effect of phenazone on prostanoid formation was found to be equal to that of indomethacin.

 

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