Neurochemical evaluation of chlordecone toxicity in the mouse
作者:
I. K. Ho,
K. Fujimori,
T. P. Huang,
H. Chang‐Tusi,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1981)
卷期:
Volume 8,
issue 5-6
页码: 701-706
ISSN:0098-4108
年代: 1981
DOI:10.1080/15287398109530106
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Plasma and brain levels of chlordecone in chlordecone‐induced motor impairment, lethal levels of chlordecone, and cumulative LD50 of chlordecone in the mouse are presented. In terms of biochemical events, the possible contributory role of neuro‐transmitters in chlordecone‐induced neurotoxicity is also discussed. On the basis of the data obtained so far, it is suggested that the dopaminergic pathway and its interaction with other neurotransmitter systems in the basal ganglia may be primarily involved in chlordecone‐induced neurotoxicity.
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