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Serum Trace Elements, Glutathione, Copper/Zinc Superoxide Dismutase, and Lipid Peroxidation in Epileptic Patients with Phenytoin or Carbamazepine Monotherapy

 

作者: Chin-San Liu,   Hong-Ming Wu,   Shu-Huei Kao,   Yau-Huei Wei,  

 

期刊: Clinical Neuropharmacology  (OVID Available online 1998)
卷期: Volume 21, issue 1  

页码: 62-64

 

ISSN:0362-5664

 

年代: 1998

 

出版商: OVID

 

关键词: Phenytoin;Carbamazepine;Superoxide dismutase;Glutathione;Lipid peroxidation.

 

数据来源: OVID

 

摘要:

Disturbance of metabolism of trace elements and antioxidants are investigated in epileptic patients with long-term therapy of anticonvulsants. One hundred and fifteen subjects including healthy controls, untreated epileptic patients, and phenytoin (PHT)- or carbamazepine (CBZ)-treated epileptic patients were recruited in this study. Serum malondialdehyde was measured as an index of extracellular lipid peroxidation. The levels of serum copper (S-Cu), serum zinc, copper/zinc superoxide dismutase (CuZn-SOD), and reduced glutathione in the serum were monitored simultaneously. The results showed that malondialdehyde, S-Cu, and CuZn-SOD levels in the serum all were significantly increased, but the glutathione level was significantly decreased, in all the epileptic patients with PHT monotherapy compared with those of the controls. However, no significant differences of these parameters in the epileptic patients with CBZ monotherapy were found except for a mild elevation of the activity of serum CuZn-SOD. We conclude that compared with PHT monotherapy, the CBZ monotherapy induced less disturbance in trace element metabolism, antioxidants, and lipid peroxidation in the serum of epileptic patients.

 

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