Effects of corticosteroid hormone on the epiphyseal growth center of immature pregnant mice
作者:
Michael Silbermann,
Shoshana Levitan,
期刊:
Cells Tissues Organs
(Karger Available online 1977)
卷期:
Volume 99,
issue 4
页码: 403-413
ISSN:1422-6405
年代: 1977
DOI:10.1159/000144863
出版商: S. Karger AG
关键词: Triamcinolone;Growth plate;Chondrocytes;Pregnant mice
数据来源: Karger
摘要:
Immature pregnant mice treated with glucocorticoid hormone (triamcinolone hexacetonide) were killed 1 week following delivery. The epiphyseal growth plates of the humerus and their cellular constituents were analyzed quantitatively. It became evident that pregnancy per se evokes a marked suppressive effect upon young cartilage cells, thus interfering with the normal process of endochondral bone formation. Pregnant mice treated with glucocorticoid hormone experienced an even higher degree of chondrocytic derangement, however, to a lesser extent than chondrocytes of nonpregnant mice treated with the hormone. It therefore appears that pregnancy-induced elevation of systemic estrogens and progesterone provides some kind of a protection against the antianabolic activity of glucocorticoids upon chondrocytes.
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