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CONFORMATIONAL CHARACTERIZATION OF CYCLOPENTAPEPTIDE, LVAL‐LPRO‐GLY‐LVAL‐GLY: A REPEATING ANALOGUE OF ELASTIN

 

作者: M.A. KHALED,   C.M. VENKATACHALAM,   H. SUGANO,   D.W. URRY,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1981）
卷期: Volume 17, issue 1  

页码: 23-33

 

ISSN:0367-8377

 

年代: 1981

 

DOI:10.1111/j.1399-3011.1981.tb01964.x

 

出版商: Blackwell Publishing Ltd

 

关键词: intramolecular H‐bond;nitrophenyl ester mediated cyclization;n.m.r. spectroscopy;theoretical energy calculations;type II β‐turn

 

数据来源: WILEY

 

摘要:

The cyclopentapeptide, ·L·Val1‐L· Pro2‐Gly3‐L· Val4‐Gly5, was synthesized and its conformational characterization was carried out using n.m.r. and theoretical energy calculations. The n.m.r. studies indicated the existence of a cis Val1‐Pro2peptide bond in water and a very strong intramolecular H‐bond between the Val1NH and Gly3C=O groups. This H‐bond forms a β‐turn (type II) placing Val4Gly5residues within the turn. Two minimum energy conformations were derived, one of which agrees very well with the s

 

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