More complex DNA structures
作者:
R. Chandrasekaran,
Struther Arnott,
R.-G. He,
R.P. Millane,
H.-S. Park,
L.C. Puigjaner,
J.K. Walker,
期刊:
Journal of Macromolecular Science, Part B
(Taylor Available online 1985)
卷期:
Volume 24,
issue 1-4
页码: 1-20
ISSN:0022-2348
年代: 1985
DOI:10.1080/00222348508248014
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Fibrous polynucleotide duplexes are very polymorphic. Detailed x-ray analysis of the D forms of poly d(AT) ·poly d(AT) and poly d(IC) ·poly d(IC) and of the B form of poly d(GC) ·poly d(GC) show that 5′RpY3′ dinucleoside monophosphates in these molecules have eithert,tort,gconformations at C3′–03′, 03′-P which lead to similar orientations of phosphate groups. On the other hand, 5′YpR3′ fragments commonly haveg,tconformations and hence a markedly different orientation of the phosphate group. Studies of the more complex structures of the C form of poly d(ACC) ·poly d(GGT) and of a pleiomeric D form of poly d(AT) ·poly d(AT) where the repeated structural motifs are hexanucleotides reveal further details of the surface “wrinkles” on DNA. In the case of the H form of poly d(A) ·poly d(T), the sugar rings in each strand are puckered differently-C2′-endo in poly d(T) and C3′-endo in poly d(A). Such heteromerous duplexes have unusually pronounced directional properties. Similar structure ma be present in some DNA-RNA hybrids. These surface feature might enable regulatory proteins and enzymes to recognize their host DNA sequences more easily in the blinding process.
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