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An Improved Fluorophotometric Method for Tear Turnover Assessment

 

作者: E. Pearce,   B. KEENAN,   and CIARAN MCRORY,  

 

期刊: Optometry and Vision Science  (OVID Available online 2001)
卷期: Volume 78, issue 1  

页码: 30-36

 

ISSN:1040-5488

 

年代: 2001

 

出版商: OVID

 

关键词: tear turnover,;fluorophotometry,;Fluorotron,;dry-eye

 

数据来源: OVID

 

摘要:

PurposeScanning fluorophotometry is considered the “gold standard” to determine tear turnover rates (TTR). In this study, we attempted to improve the precision of basal TTR by fluorophotometry through a number of methodological changes.MethodsBy means of a timer program that produces audio cues, a new methodology that ensures confluence and a constant thickness of the tear film and minimization of reflex lacrimation as a result of the inhibition of the blink reflex was developed. This was compared with the standard protocol, both in a paired study and by a review of unpaired data. The minimum length of time required to monitor TTR measurements was also investigated.ResultsA significant improvement in correlation coefficient (r) of the log decay curve was observed as a result of changes in the protocol in both the paired (p = 0.016) and unpaired study (p < 0.0001). We determined that it was sufficient to monitor TTR for 10 min to obtain accurate results.ConclusionsWe advocate that the changes be adopted as widely as possible for the precise and rapid measurement of basal tear turnover rates.

 

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