Bunyaviridae
作者:
D.H.L. Bishop,
C.H. Calisher,
J. Casals,
M.P. Chumakov,
S.Ya. Gaidamovich,
C. Hannoun,
D.K. Lvov,
I.D. Marshall,
N. Oker-Blom,
R.F. Pettersson,
J.S. Porterfield,
P.K. Russell,
R.E. Shope,
E.G. Westaway,
期刊:
Intervirology
(Karger Available online 1980)
卷期:
Volume 14,
issue 3-4
页码: 125-143
ISSN:0300-5526
年代: 1980
DOI:10.1159/000149174
出版商: S. Karger AG
关键词: Phlebovirus;Bunyaviridae;Nairovirus;Taxonomy;Uukuvirus;Viruses;Bunyavirus
数据来源: Karger
摘要:
The family Bunyaviridae comprises over 200 viruses (serotypes, subtypes, and varieties) that infect vertebrates and/or invertebrates. Four genera of viruses have been defined (Bunyavirus, Nairovirus, Phlebovirus, and Uukuvirus). The main characteristics of the member viruses are: (i) the virus particles are for the most part uniformly spherical, 80–110 nm in diameter, and possess a unit membrane envelope from which protrude polypeptide spikes 5–10 nm long; (ii) the viruses have three helical nucleocapsids, often in the form of supercoiled circles, each consisting of a single species of single-stranded RNA, a major nucleocapsid polypeptide, N, and at least in some cases minor amounts of a large polypeptide which may be a transcriptase component; (iii) the genome is composed of three species of RNA (L, large; M, medium; and S, small), organized in end-hydrogen bonded circular structures; (iv) most viruses have three major virion polypeptides (N, and two surface polypeptides, designated Gl and G2); (v) for at least some member viruses, the virions have been shown to contain an RNA-directed RNA polymerase, believed to be responsible for the synthesis of viral complementary mRNA, so that bunyaviruses are considered to be negative-stranded viruses; (vi) at least some bunyaviruses are capable of heterologous virus genome segment reassortment and can form recombinant viruses at high or low frequency; (vii) viruses appear to mature primarily at smooth membrane surfaces and accumulate in Golgi vesicles and saccules, or nearby; (viii) transovarial, venereal and/or transstadial transmission in arthropods has been shown to occur for some members of the fam
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