The role of the thymus in the ontogeny of the immune system
作者:
Donald Metcalf,
Margaret Brumby,
期刊:
Journal of Cellular Physiology
(WILEY Available online 1966)
卷期:
Volume 67,
issue S1
页码: 149-167
ISSN:0021-9541
年代: 1966
DOI:10.1002/jcp.1040670413
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe proper development of the organs of the immune system is dependent on at least three factors: (1) the development of anlagen with the capacity to trap antigens and support the proliferation of lymphoid and plasma cell precursors; (2) the production by the bone marrow of lymphoid and plasma cell precursors which seed in the lymphoid organs; and (3) the thymus, which seeds reactive cells to the lymphoid organs and produces a humoral factor stimulating antigen‐triggered proliferation of primitive lymphoid and plasma cells. Studies on cell population changes in the lymph nodes following thymectomy in mice confirm earlier evidence that most cells produced in the thymus do not seed to the lymphoid organs, but die locally in the thymu
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