Plasma Levels of the Anaphylatoxins C3a and C4a in Patients with IgA Nephropathy/Henoch-Schönlein Nephritis
作者:
H.H.A. Abou-Ragheb,
A.J. Williams,
C.B. Brown,
A. Milford-Ward,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 1
页码: 22-26
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186989
出版商: S. Karger AG
关键词: Anaphylatoxin C3a, C4a;Complement C3, C4;Henoch-Schönlein nephritis;IgA nephropathy
数据来源: Karger
摘要:
Measurements of plasma anaphylatoxins C3a and C4a were carried out as an indicator of in vivo complement activation in 46 patients suffering from IgA nephropathy/Henoch-Schönlein nephritis. There was a significant correlation between plasma levels of C4a and plasma creatinine and urea. We also found a significant correlation of plasma levels of C3a with plasma creatinine. We propose that the measurement of anaphylatoxin levels provides a sensitive indicator of in vivo complement activation and may serve as an additional method for monitoring the progress of disease in these patients
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