Lead and the terminal mitochondrial enzymes of haem biosynthesis
作者:
E. Rossi,
S. Taketani,
P. Garcia‐Webb,
期刊:
Biomedical Chromatography
(WILEY Available online 1993)
卷期:
Volume 7,
issue 1
页码: 1-6
ISSN:0269-3879
年代: 1993
DOI:10.1002/bmc.1130070102
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractLead exposure causes increases in urinary coproporphyrin excretion and the accumulation of zinc protoporphyrin in red cells. In the conventional view of the effect of lead on haem biosynthesis, the accumulation of these metabolites results from lead inhibition of two of the mitochondrial enzymes of haem biosynthesis, corproporphyrinogen oxidase (EC 1.3.3.3.) and ferrochelatase (EC 4.99.1.1). This review critically assesses the evidence for the inhibition of these enzymes. We consider this evidence to be inconclusive and alternative explanations for the increased concentrations of coproporphyrin and zinc protoporphyrin are proposed.
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