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Allocytotoxic T cell clones: both Leu 2+3−and Leu 2−3+T cells recognize class I histocompatibility antigens

 

作者: Neal Flomenberg,   Kazuyuki Naito,   Ellen Duffy,   Robert W. Knowles,   Robert L. Evans,   Bo Dupont,  

 

期刊: European Journal of Immunology  (WILEY Available online 1983)
卷期: Volume 13, issue 11  

页码: 905-911

 

ISSN:0014-2980

 

年代: 1983

 

DOI:10.1002/eji.1830131109

 

出版商: WILEY‐VCH Verlag GmbH

 

数据来源: WILEY

 

摘要:

AbstractT cell clones were selected which were cytotoxic for human class I major histocompatibility target antigens. Specificity was based on target cell panel studies and inhibition by monoclonal antibodies to class I determinants. Eight clones were Leu 2+3−. The cytotoxicity of these clones was inhibited by antibody to the Leu 2 antigen. Two clones expressed the Leu 2−3+phenotype and were not inhibited by anti‐Leu 2a or anti‐Leu 3a antibodies. These studies indicate that class I‐specific cytotoxic T cells are distributed in both T cell subsets, though predominantly in the Leu 2+3−group. In addition, these studies suggest that the Leu 3 molecule may not function in identical fashion in Leu 3+cytotoxic T cells, which recognize class I target antigens, as in those which recognize class

 

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