Allocytotoxic T cell clones: both Leu 2+3−and Leu 2−3+T cells recognize class I histocompatibility antigens
作者:
Neal Flomenberg,
Kazuyuki Naito,
Ellen Duffy,
Robert W. Knowles,
Robert L. Evans,
Bo Dupont,
期刊:
European Journal of Immunology
(WILEY Available online 1983)
卷期:
Volume 13,
issue 11
页码: 905-911
ISSN:0014-2980
年代: 1983
DOI:10.1002/eji.1830131109
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractT cell clones were selected which were cytotoxic for human class I major histocompatibility target antigens. Specificity was based on target cell panel studies and inhibition by monoclonal antibodies to class I determinants. Eight clones were Leu 2+3−. The cytotoxicity of these clones was inhibited by antibody to the Leu 2 antigen. Two clones expressed the Leu 2−3+phenotype and were not inhibited by anti‐Leu 2a or anti‐Leu 3a antibodies. These studies indicate that class I‐specific cytotoxic T cells are distributed in both T cell subsets, though predominantly in the Leu 2+3−group. In addition, these studies suggest that the Leu 3 molecule may not function in identical fashion in Leu 3+cytotoxic T cells, which recognize class I target antigens, as in those which recognize class
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