Synthesis and Properties of Hydrophilic Copolymers Containing 5-Fluorouracil, Thymine, or Adenine
作者:
Mitsuru Akashi,
Koichi Beppu,
Ikuo Kikuchi,
Noriyuki Miyauchi,
期刊:
Journal of Macromolecular Science: Part A - Chemistry
(Taylor Available online 1986)
卷期:
Volume 23,
issue 10
页码: 1233-1249
ISSN:0022-233X
年代: 1986
DOI:10.1080/00222338608069491
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Hydrophilic copolymers containing 5-fluorouracil (5-FU), thymine, or adenine were prepared by the free-radical copolymerization of methacryloyl-type monomers containing them with water-soluble vinyl monomers such as acrylic acid, methacrylic acid, vinylpyrroli-done, acrylamide, and 4(5)-vinylimidazole with AIBN as initiator. Complex formation between the copolymers and RNA and between the copolymers having complementary nucleic acid bases in aqueous solution and a DMSO-ethylene glycol was studied by means of UV spectroscopy. These copolymers were found to release the N-hydroxyethyl derivatives of 5-FU, thymine, or adenine by hydrolysis of the ester of the polymer side chain under mild conditions. The effects of the kind of water-soluble comonomer, temperature, pH, and the imidazole group as catalyst on the hydrolysis of the ester are discussed.
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