The effectiveness of the carbon dioxide laser was evaluated in the treatment of penile, anorectal, and urethral condylomata acuminata in 40 men. All but six cases of urethral condylomata were prior conventional treatment failures. Postlaser follow-up ranged between one and two years, with an average of 16 months. No patients were lost to follow-up. Postlaser recurrence rates were 7.5%. No postoperative complications occurred in this series. Carbon dioxide laser is highly successful for treating persistent and/or extensive urogenital and anal condylomata in the male patient.