AbstractThis paper is concerned with the sequence regulation of monomeric units in a series of binary and ternary copolymerizations which proceed without any added catalyst or initiator. The binary copolymerization is consisted of the combination of a nucleophilic monomer (MN) and an electrophilic monomer (ME). The interaction between the two monomers generates a zwitterion of a 1:1 adduct, which is the key intermediate in the copolymerization producing 1:1 alternating copolymer. The varieties of MNand MEmonomers, the structures of key intermediates of zwitterions, and the schema of copolymerizations have been discussed. In addition, the “Sequence–Ordered 1:1:1 Terpolymerization” (producing terpolymers of a type .…ABCABCABC….) and “2:1 Binary Copolymerization” (producing copolymers of a type of .…ABBABBABB….) are described, which have been developed on the basis of the above binary 1:1 alternating