High density cAMP‐gated channels at the ciliary membrane in the olfactory receptor cell
作者:
Takashi Kurahashi,
Akimichi Kaneko,
期刊:
NeuroReport
(OVID Available online 1991)
卷期:
Volume 2,
issue 1
页码: 5-8
ISSN:0959-4965
年代: 1991
出版商: OVID
关键词: Olfactory receptor cell;Signal transduction;cAMP-gated channel;Single channel current;Channel distribution;Cilia
数据来源: OVID
摘要:
SPATIAL distribution of the cAMP-gated channel was investigated in amphibian olfactory receptor cells. Low doses of cAMP applied to the cytoplasmic side of a membrane patch excised from cilia produced single channel activity of unitary conductance 28pS. Variance analysis showed that the ciliary membrane contained 920 cAMP gated-channels/μm2in the newt and 2400 channels/μm2in the toad. In contrast, the membrane of the dendrite and cell body contained only 2 cAMP-gated channels/μm2(newt) and 6 channels/μm2(toad). Thus, there is a high density of cAMP-gated channels in the cilia where olfactory transduction is thought to take place.
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