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New cyclobutyl analogs of adenosine and guanosine. Part1. Synthesis of the 9‐[3,3‐bis(hydroxymethyl)cyclobutyl]purine nucleoside analogs

 

作者: Hassane Boumchita,   Michel Legraverend,   Emile Bisagni,   Christiane Huel,  

 

期刊: Journal of Heterocyclic Chemistry  （WILEY Available online 1990）
卷期: Volume 27, issue 6  

页码: 1815-1819

 

ISSN:0022-152X

 

年代: 1990

 

DOI:10.1002/jhet.5570270655

 

出版商: Wiley‐Blackwell

 

数据来源: WILEY

 

摘要:

AbstractThe synthesis of 1‐amino‐3,3‐bis(benzyloxymethyl)cyclobutane has been performed from 3,3‐bis(benzyloxymethyl)cyclobutanone,viathe corresponding oxime which was reduced with lithium aluminum hydride. The amine thus obtained led to two new cyclobutyl analogs of adenosine and guanosine which were devoid of antiviral activity against HSV‐1, HCMV and HIV in cel

 

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